REAL Studio 2010 Release 5 arrived this week, and now includes "Web Edition".
This tool is a huge breakthrough, allowing you to create desktop-style apps deployed in a web browser. You build web apps in the same manner as desktop apps -- drag and drop widgets to forms, add programming to the widgets, and write classes as well. All in the same language: REALbasic. Same code editor and debugger, same commands and libraries. Except of course the web app widgets are a little different and more limited given the limitations of browser technologies and given that Web Edition is a new 1.0 feature set though built on top of an established toolset.
The wonderful thing about Web Edition is what is not in it: